Atopic dermatitis
Characteristic Features
The word ‘atopy,’ which was
introduced by Coca in1923, is a combination of ‘a’ and ‘topia’, which mean
without and place, respectively. Therefore, atopy means a disease without a
place, which is a new disease entity. Allergic reactions (Type I or IV) are not
solely responsible for atopic dermatitis, as it was formerly thought. Multiple
and diverse factors contribute to the onset of atopy. It is also called ‘a
strange disease’ because its cause cannot be identified as a previously known
allergic reaction. Atopic dermatitis is associated with atopic diathesis, which
is sensitivity to pollen, ticks, house dust, or animal dander. Pollinosis (hay
fever), asthma and urticaria are usually caused by hereditary atopic diathesis
(see previous page). Clinical features of atopic dermatitis include a red face,
Denie’s line of the lower eyelid and dry itchy skin. White dermographism and
acetylcholine delayed blanch phenomenon are regarded as abnormal blood vessel
reactions which never occur in normal people. The tendency of atopic persons to
have such reactions to various kinds of substances has been attributed to the
onset of atopic diseases. Also these abnormal reactions are responsible for the
tendency to vasoconstriction. Even if a skin test is positive, or if the
concentration of IgE antibodies is extremely high, it is not always possible to
conclude that these are the causes of atopic dermatitis.
Adult-type Atopic
Dermatitis
It is recognized that adult-type
atopic dermatitis, characterized by a reddish face, is recently increasing in
number. The reddish face is accompanied by reddish lesions and edematous or
acne-like papules, both of which are intensely itchy and become exudative and
crusted. Misuse of corticosteroid ointment is blamed as a cause of atopic red
face. In addition, stress, lack of self-control (e.g., irregular sleeping and
eating patterns) and immaturity (over dependency on parents) tend to make the
disease worse. Adult-type atopic dermatitis is so difficult to cure that atopic
patients sometimes become depressed and come to distrust their doctors. They
may soon stop using the corticosteroid ointment and become dependent on so
called “atopy businesses” which offer miracle cures. As a result, the patients’
dermal symptoms gradually get worse.
For a long time it was
considered that stress was an important factor, which aggravated atopic
dermatitis. For example, students preparing for college entrance exams got
better after success, when relieved from their mental stress. Another example
is that of a Tokyo resident whose atopic dermatitis disappeared when she went
back home to the countryside. I believe that there is no doubt that stress has
something to do with the cause of adult-type atopic dermatitis, but that there
is some additional pathogenesis, an example of which is a contact dermatitis
caused by chemical sensitivity (to be discussed later.).